Supplements

Evidence-based supplements. No hype. Just facts.


Products chosen by ingredient and evidence, grouped by what they are for. Each one has been looked into and judged among the best in its class. One of the real problems with supplements in the United States is quality control, so I have tried to find products that are third party tested.

Roscoe Nelson, MD
“Most of what gets sold as a supplement is a real ingredient wrapped in claims it cannot support.”Dr. Roscoe Nelson

Where these come from, and what I earn

I use Fullscript to dispense supplements. It is run through my clinic, Peri Health & Hormones, so the storefront carries the Peri name rather than PeeDoc. I earn a margin on what is sold through it, and I am telling you that so you can weigh it. I picked these products because I take some of them myself, and I have recommended others to my family. This is research based quality.

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How to read this page

Each product is here for a reason. Two things are missing on purpose. Dosing is one: how much of anything you should take depends on your labs and your history, and that conversation belongs in a visit, not on a web page. Hype is the other. Where the evidence is strong I say so, and where it is thin I say that too.

Foundational

  • PhytoMulti (with and without iron). A multivitamin as backstop, not as strategy. The version with iron is for people who actually need iron, which labs decide.
  • Omega-3 fish oil (OmegaGenics 5-in-1). Cardiovascular and anti-inflammatory support with a deep evidence base. Quality means verified purity and a stated EPA/DHA content.
  • Magnesium glycinate. The form absorbs well and is gentle on the gut. Sleep, muscle cramps and regularity are the common reasons.
  • B complex and B-12 with intrinsic factor. For depleted or poorly absorbing patients, including many on metformin or acid blockers.
  • Zinc bisglycinate. Immune function and male reproductive health, in an absorbable form.

Hormone support

  • DHEA. A hormone precursor with real effects, which is exactly why it belongs behind labs rather than guesswork. I use it myself.
  • Ashwagandha. Reasonable evidence for stress and sleep. Quality varies widely between brands, which is most of why this one is here.
  • Chaste tree berry. A long history in cycle-related symptoms, with modest but honest evidence.
  • Phosphatidylserine. Used for stress and cortisol support. Evidence is moderate.
  • Boron (glycinate). Interesting data on bone, and it can sometimes be used to lower sex hormone binding globulin, which frees up more of the testosterone you already make. Labs tell us whether that lever is worth pulling for you.
  • Pregnenolone. A hormone precursor with more theory than trial behind it. The evidence is thin, but I use it myself, and I have watched my own downstream hormone numbers improve.
  • Estrogen metabolism support (EstroDIM). I use DIM myself. Available through a practitioner protocol rather than the open shelf.

Thyroid

  • Selenium. Solid evidence in autoimmune thyroid disease, and one of the few supplements with a specific thyroid indication.
  • Thyroid support complex. A combination product for gland support. It is support, not a replacement for thyroid medication when medication is needed.
  • Iodine. Worth more explanation than it usually gets. Thyroid levels are not a good marker of iodine stores, and iodine does more than feed the gland: it is used to help transport hormone into the cell where the work actually happens. Our current salt preferences work against us here, because Mediterranean sea salt and pink Himalayan salt are not supplemented with iodine the way ordinary iodized table salt is. I take iodine myself. One caution stands: in autoimmune thyroid disease iodine can aggravate the problem, so know your antibody status before starting it.

Metabolic

  • Dihydroberberine. Berberine has real glucose data, and this form absorbs better with less gut upset.
  • Metabolic Xtra and alpha lipoic acid. Insulin-sensitivity support with moderate evidence.
  • Sensitol. Inositol-based, with its best evidence in PCOS: inositol helps the cell hear insulin's signal, and when insulin comes down, so do the androgens that drive the symptoms.
  • FiberMend. Most people are short on fiber, and fiber moves lipids, glucose and satiety all at once. It slows how fast sugar reaches the bloodstream, which keeps glucose steadier and blunts the spikes some of our dietary choices produce. The least glamorous item on this page and one of the most useful.

Lipids

  • Red yeast rice (and RYR Synergy). The one supplement with honest LDL-lowering evidence, because it contains a naturally occurring statin-class compound. That also means it deserves statin-level respect: liver checks and no combining with a prescription statin.
  • Pantethine. A vitamin B5 derivative with modest but real lipid data.
  • Niacinamide. Worth being precise about: this is the no-flush form of vitamin B3, and it is not the form used for cholesterol. It is here for other reasons, including skin and cellular support, not as a lipid agent.

Urinary tract

  • TheraCran One. Cranberry standardized to 36 mg of proanthocyanidins per capsule, measured by the BL-DMAC method, stated on the label. That sentence is the whole point: most cranberry products either do not quantify their PACs or use a non-comparable assay, and 36 mg is the number the prevention literature uses. This is the only product in the catalog I found that states both.
  • Cranberry with D-mannose. Some people have success with D-mannose, particularly for E. coli infections. Its PAC content is not quantified, so it is a different tool than the one above, not a substitute.
  • Citrate (potassium and magnesium citrate combinations). For kidney stone formers. Low urinary citrate is one of the most common findings on a 24-hour urine collection, and citrate works by binding calcium in the urine and blocking crystal growth. If you form stones, this is one of the highest-value preventions there is, and it should be guided by your collection results. Ask me and I will set you up with the right combination.

Prostate and men's health

  • Prostate 2.4 and Prostate Supreme. Combination formulas built around saw palmetto, beta sitosterol and the nutrients the prostate uses most. What they actually do is support urinary comfort and flow in men with an enlarging gland, and that is the claim they can stand behind.
  • Prostate PQ (flower pollen extract). This one is specific: pollen extract has real randomized-trial support in chronic prostatitis and chronic pelvic pain. That is where its evidence lives, and that is the only use I will put my name on.

Male fertility

  • ConceptionXR (Reproductive Health and Motility Support). Honest framing: the evidence for micronutrient formulas in male fertility is modest. The 90-day supply is not marketing, it is biology: a sperm takes about 74 days to mature, so any change takes a full cycle to show up in a semen analysis.

Longevity and cellular

  • Mitopure (urolithin A). Among the better-studied of the newer longevity compounds, with human data on muscle endurance.
  • Ubiquinol. The absorbable form of CoQ10. Relevant for anyone on a statin, and for energy metabolism generally.
  • Curcumin phytosome. Anti-inflammatory with decent evidence, in a form that actually absorbs.
  • NAC and glutathione (liposomal and reduced). Antioxidant support and the precursor pathway behind it.
  • Creatine. The best-evidenced sports supplement in existence, and increasingly interesting for muscle preservation during weight loss and aging. The brain runs on the same energy system: there is growing evidence for mental clarity and memory, especially when sleep or stress has drained the tank.
  • Collagen. Reasonable evidence for skin and joints. Pair it with protein adequacy generally or it is expensive protein.

Bone and blood

  • Vitamin D with K2 (K-Force). Low vitamin D levels are associated with weaker bones and more fractures, more infections, low mood, weaker muscles and falls in older adults. Practitioner protocol rather than the open shelf, because dosing vitamin D properly means knowing your level first.
  • Iron (Reacted Iron). Also protocol-only, and deliberately so. Iron helps when you are deficient and harms when you are not, so it follows labs, never a guess. Ferritin, not a blood count, is how deficiency is found.

A few of these need a conversation first

Three groups on this page sit behind practitioner protocols rather than the open store: estrogen metabolism support, vitamin D with K2, and iron. That is not friction for its own sake. Each one should follow a lab value, and the protocol is how I attach the product to your actual numbers. Ask at your visit, or through the contact page, and I will set it up.

Questions I hear every week

Direct answers first. The details follow.

Are supplements regulated like medications?

No, and understanding the difference protects you. Supplements reach shelves without proving effectiveness or safety first; the FDA acts after problems surface. Content frequently fails to match labels, and contamination with actual drugs happens in exactly the categories men shop, sexual enhancement above all. This is why my dispensary carries professional brands with third-party verification, and why an FDA-approved medication and a supplement making the same promise are not competing on the same field.

How do I know a supplement brand is trustworthy?

Look for third-party verification, USP, NSF or equivalent independent testing, transparent ingredient amounts rather than proprietary blends, and standardized actives where they matter, like cranberry stating its measured proanthocyanidin content. Professional lines sold through practitioners live on repeat clinical use rather than podcast ads. And skepticism scales with the promise: the more a label claims, the more proof it owes. The brands on my shelf earned their place by ingredient, dose and verification, not marketing.

Should I get labs before starting supplements?

For several of them, yes, and it is not gatekeeping. Iron helps deficiency and harms excess, so it follows ferritin, never a guess. Vitamin D dosing is smarter with a level. Boron for hormones only makes sense against SHBG and testosterone values. Iodine needs thyroid antibody awareness first. Labs turn supplementation from folklore into adjustment of measured gaps, which is the entire difference between my formulary and a grocery aisle. Test, then supplement, then retest what mattered.

References

  1. American Urological Association: clinical guidelines

Last medically reviewed August 2026 by Roscoe S. Nelson, MD, FACS, board-certified urologist.

Peri Health & Hormones

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Peri Health & Hormones is where Dr. Nelson provides current clinical care in hormones, metabolic health, sexual health, recurrent UTI and selected procedures.

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807 E. Pioneer Rd. Suite 105
Draper, UT 84020